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The Cure ALD Foundation is a public non-profit organization founded in 2003 by Bill and Diane Zmrzel after their son, Wyatt, was diagnosed with Adrenoleukodystrophy or ALD. The Cure ALD foundation seeks to fund research to find a cure. Please feel free to search our site to learn more about ALD, our family, and how you can help.

Childhood Cerebral Adrenoleukodystrophy (ALD)
This is the most common form of ALD, representing about 45% of all ALD cases. It is characterized by an inflammatory process that destroys the myelin, causing relentless progressive deterioration to a vegetative state or death, usually within five years.

Adrenomyeloneuropathy (AMN)
The majority of other cases of the disease occur as the adult form, known as AMN. In about half of the sons who inherit the mutated ALD gene, symptoms of the disease do not develop until young adulthood, and in general, they progress more slowly. Beginning in their 20s and 30s, these young men exhibit neurological based motor lesions in their extremities.

These lesions progress over many years and are inevitably accompanied by moderate to severe handicap. In approximately one third of these patients the central nervous system also becomes involved. These young men undergo the same mental and physical deterioration as the previously described boys. The progress of the disease is slower, usually declining to a vegetative state and/or death in as soon as 5 years, but often much longer. There is no FDA approved effective treatment for the adult onset of ALD, which is commonly referred to as adrenomyeloneuropathy (AMN); rather, medication and therapies are employed in a palliative manner.